Subclinical kidney injury before and 1 year after bariatric surgery among adolescents with severe obesity.

ABSTRACT:

Objective

To assess subclinical kidney injury in adolescents with severe obesity by measuring biomarkers of early kidney disease and to assess changes in the levels of these biomarkers following bariatric procedures.

Methods

Twenty-two adolescents undergoing bariatric surgery with no microalbuminuria and normal kidney function were selected. Urinary NGAL, IL-18, and KIM-1 were measured at baseline, 6 and 12 months postoperatively. Biomarker levels were compared to 44 age-gender-matched lean controls.

Results

Subjects with obesity had a mean baseline BMI of 48 kg/m(2) that decreased by 34% at 1-year follow-up. Urine NGAL, IL-18, and KIM-1 were significantly elevated in subjects with obesity compared to lean controls at baseline. The obese cohort had a further significa

SUBMITTER: Xiao N 

PROVIDER: S-EPMC4446189 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature