A model to determine colorectal cancer risk using common genetic susceptibility loci.

ABSTRACT:

Background & aims

Risk for colorectal cancer (CRC) can be greatly reduced through screening. To aid in the development of screening strategies, we refined models designed to determine risk of CRC by incorporating information from common genetic susceptibility loci.

Methods

By using data collected from more than 12,000 participants in 6 studies performed from 1990 through 2011 in the United States and Germany, we developed risk determination models based on sex, age, family history, genetic risk score (number of risk alleles carried at 27 validated common CRC susceptibility loci), and history of endoscopic examinations. The model was validated using data collected from approximately 1800 participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, condu

SUBMITTER: Hsu L 

PROVIDER: S-EPMC4446193 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature