Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.

ABSTRACT:

Background and aims

Non-alcoholic steatohepatitis (NASH), the potentially progressive form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time. Although there are several animal models of NASH, consensus regarding the optimal model is lacking. We aimed to compare features of NASH in the two most widely-used mouse models: methionine-choline deficient (MCD) diet and Western diet.

Methods

Mice were fed standard chow, MCD diet for 8 weeks, or Western diet (45% energy from fat, predominantly saturated fat, with 0.2% cholesterol, plus drinking water supplemented with fructose and glucose) for 16 weeks. Liver pathology and metabolic profile were compared.

Results

The metabolic profile associated with human NASH was better mimicked by Wester

SUBMITTER: Machado MV 

PROVIDER: S-EPMC4446215 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature