Effect of mineralocorticoid receptor blockade on hippocampal-dependent memory in adults with obesity.

ABSTRACT:

Objective

The hippocampus is crucial for paired-associate learning. Obesity is associated with increased mineralocorticoid receptor (MR) activity in peripheral and possibly central tissues, decreased hippocampal size in humans, and impaired hippocampal learning in rodents. The MR is expressed in hippocampal neurons, and MR blockade improves hippocampal learning in obese animals. The goal of the study was to determine whether MR blockade would modulate paired-associate learning in men and women with obesity.

Methods

Men and women ages 20-61 years with BMI between 30-45 kg/m(2) were randomly assigned to placebo (n = 11; 7 women) or 50 mg spironolactone daily (n = 12; 7 women) for six weeks. At baseline and post-treatment, subjects underwent a clinical and hormonal evaluation.

SUBMITTER: Rotenstein LS 

PROVIDER: S-EPMC4446234 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature