Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.

ABSTRACT:

Background & aims

The Drug-Induced Liver Injury Network is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study.

Methods

In an observational longitudinal study, we began collecting data on eligible individuals with suspected DILI in 2004, following them for 6 months or longer. Subjects were evaluated systematically for other etiologies, causes, and severity of DILI.

Results

Among 1257 enrolled subjects with suspected DILI, the causality was assessed in 1091 patients, and 899 were considered to have definite, highly likely, or probable DILI. Ten percent of patients died or underwent liver transplantation, and 17% had chronic liver injury. In the 89

SUBMITTER: Chalasani N 

PROVIDER: S-EPMC4446235 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature