Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome.

ABSTRACT:

Background

There is increased risk of developing psychosis in 22q11.2 deletion syndrome (22q11DS). Although this condition is associated with morphologic brain abnormalities, simultaneous examination of multiple high-resolution measures of cortical structure has not been performed.

Methods

Fifty-three patients with 22q11DS, 30 with psychotic symptoms, were compared with demographically matched nondeleted youths: 53 typically developing and 53 with psychotic symptoms. High-resolution magnetic resonance imaging measures of cerebral volume, cortical thickness, surface area, and an index of local gyrification were obtained and compared between groups.

Results

Patients with 22q11DS demonstrated global increases in cortical thickness associated with reductions in surface ar

SUBMITTER: Schmitt JE 

PROVIDER: S-EPMC4446247 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature