Association between Benzodiazepine Use and Dementia: A Meta-Analysis.

ABSTRACT:

Background

The association between long-term benzodiazepine use and risk of dementia remains controversial. Therefore, current study aimed to quantify this association, and to explore a potential dose-response pattern.

Methods

We searched PubMed, Embase and the Cochrane Library through August 17, 2014. We included nested case-control or prospective cohort studies that provided risk estimates on the association of benzodiazepine use with risk of dementia, and a clear definition of status of benzodiazepine use. Overall effect size was calculated using a random-effects model.

Findings

Six studies were eligible for inclusion, involving 11,891 dementia cases and 45,391 participants. Compared with never users, pooled adjusted risk ratios (RRs) for dementia were 1.49 (95% co

SUBMITTER: Zhong G 

PROVIDER: S-EPMC4446315 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature