H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes.

ABSTRACT: Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC chromatin remodeling complex to stress-responsive genes and rsc deficient cells display reduced induction of gene expression. Here we show that the absence of H3K4 methylation, either achieved by deletion of the SET1 methyltransferase or by amino acid substitution of H3K4, bypasses the requirement of RSC for stress-responsive gene expression. Monomethylation of H3K4 is specifically inhibiting RSC-independent chromatin remodeling and thus, it prevents osmostress-induced gene expression. The absence of H3K4 monomethylation permits that the association of alternative remodeler

SUBMITTER: Nadal-Ribelles M 

PROVIDER: S-EPMC4446418 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature