Functional diversity of anti-lipopolysaccharide factor isoforms in shrimp and their characters related to antiviral activity.

ABSTRACT: Anti-lipopolysaccharide factor (ALF) is a small protein with broad-spectrum antimicrobial activity, which has potential application in the disease control. Previously, we isolated seven ALF isoforms from the Chinese shrimp Fenneropenaeus chinensis. In the present study, their distributions in tissues of shrimp were analyzed and the data showed that different isoforms had different expression profiles, which suggested that they might have different functions. Then, the functions of different isoforms were studied by analyzing the antibacterial and antiviral activities of the functional domain of ALFs, the LPS-binding domain (LBD), which were synthesized by chemical methods. Different ALFs showed distinct antibacterial and antiviral activities, which were consistent with their diverse tissue

SUBMITTER: Li S 

PROVIDER: S-EPMC4446596 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature