Anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet-induced obese rats.

ABSTRACT:

Objective

This study is to evaluate the anti-obese effects of glucosamine (GLC) and chitosan oligosaccharide (COS) on high-fat diet-induced obese rats.

Methods

The rats were randomly divided into twelve groups: a normal diet group (NF), a high-fat diet group (HF), Orlistat group, GLC high-, middle-, and low-dose groups (GLC-H, GLC-M, GLC-L), COS1 (COS, number-average molecular weight ≤1000) high-, middle-, and low-dose groups (COS1-H, COS1-M, COS1-L), and COS2 (COS, number-average molecular weight ≤3000) high-, middle-, and low-dose groups (COS2-H, COS2-M, COS2-L). All groups received oral treatment by gavage once daily for a period of six weeks.

Results

Rats fed with COS1 gained the least weight among all the groups (P < 0.01), and these rats lost more weight than th

SUBMITTER: Huang L 

PROVIDER: S-EPMC4446603 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature