Eunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta.

ABSTRACT: Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.

SUBMITTER: Huang TZ 

PROVIDER: S-EPMC4446604 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature