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Eunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta.

ABSTRACT: Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6?-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.

SUBMITTER: Huang TZ 

PROVIDER: S-EPMC4446604 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Eunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta.

Huang Tzu-Zin TZ   Chen Bo-Wei BW   Huang Chiung-Yao CY   Hwang Tsong-Long TL   Uvarani Chokkalingam C   Dai Chang-Feng CF   Sung Ping-Jyun PJ   Su Jui-Hsin JH   Sheu Jyh-Horng JH  

Marine drugs 20150430 5

Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase  ...[more]

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