Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.

ABSTRACT: New carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases were synthesized and evaluated as potential anti-HIV and anti-HCV agents. Among the synthesized carbocyclic nucleoside analogs, the pyrazole amide 15f exhibited modest selective anti-HIV-1 activity (EC₅₀ = 24 µM).

SUBMITTER: Cho JH 

PROVIDER: S-EPMC4446795 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature