GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury.

ABSTRACT: After kidney ischemia/reperfusion (I/R) injury, monocytes home to the kidney and differentiate into activated macrophages. Whereas proinflammatory macrophages contribute to the initial kidney damage, an alternatively activated phenotype can promote normal renal repair. The microenvironment of the kidney during the repair phase mediates the transition of macrophage activation from a proinflammatory to a reparative phenotype. In this study, we show that macrophages isolated from murine kidneys during the tubular repair phase after I/R exhibit an alternative activation gene profile that differs from the canonical alternative activation induced by IL-4-stimulated STAT6 signaling. This unique activation profile can be reproduced in vitro by stimulation of bone marrow-derived macrophages with co

SUBMITTER: Huen SC 

PROVIDER: S-EPMC4446881 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature