An efficient method for the preparation of styrene derivatives via Rh(III)-catalyzed direct C-H vinylation.

ABSTRACT: The development of a method for the Rh(III)-catalyzed direct vinylation of an aromatic C-H bond to give functionalized styrenes in good yield, using vinyl acetate as a convenient and inexpensive vinyl source, is reported. High functional group tolerance is demonstrated for electronically distinct arenes as well as different directing groups. Mechanistic investigation resulted in the characterization of a novel rhodium-metallacycle, which represents the first X-ray structure of a [1,2]-Rh(III)-alkenyl addition adduct.

SUBMITTER: Otley KD 

PROVIDER: S-EPMC4446975 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature