Identifying Common Genetic Risk Factors of Diabetic Neuropathies.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is a global public health problem of epidemic proportions, with 60-70% of affected individuals suffering from associated neurovascular complications that act on multiple organ systems. The most common and clinically significant neuropathies of T2DM include uremic neuropathy, peripheral neuropathy, and cardiac autonomic neuropathy. These conditions seriously impact an individual's quality of life and significantly increase the risk of morbidity and mortality. Although advances in gene sequencing technologies have identified several genetic variants that may regulate the development and progression of T2DM, little is known about whether or not the variants are involved in disease progression and how these genetic variants are associated with diabetic neuropath

SUBMITTER: Witzel II 

PROVIDER: S-EPMC4447004 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature