The Effect of Cage Space on Behavior and Reproduction in Crl:CD1(Icr) and C57BL/6NCrl Laboratory Mice.

ABSTRACT: Recommendations for the amount of cage space required for female mice with litters were first made in the 2011 Guide for the Care and Use of Laboratory Animals. We hypothesized that if a difference in mouse behavior and reproduction exists within the limits of commercially available caging, this difference would be detected between the smallest and largest cages. C57BL/6NCrl and Crl:CD1(Icr) breeding mice were randomly assigned to a cage treatment: LP 18790 (226 cm2); A RC1 (305 cm2); A N10 (432 cm2); T 1291 (800 cm2) and a breeding configuration: single (male removed after birth); pair (1 male + 1 female); or trio (1 male + 2 females) in a factorial design for 12 weeks. All cages received 8-10 g of nesting material and nests were scored weekly. Pups were weaned between post-natal day 18 a

SUBMITTER: Gaskill BN 

PROVIDER: S-EPMC4447268 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature