Acute sirolimus overdose: a multicenter case series.

ABSTRACT:

Background

There are few data relating to sirolimus overdose in the medical literature. Our objectives were to describe all cases of overdose with sirolimus reported to Swiss, German and Austrian Poisons Centres between 2002-2013.

Methods

An observational case-series analysis was performed to determine circumstances, magnitude, management and outcome of sirolimus overdose.

Results

Five cases of acute sirolimus overdose were reported--three in young children and two in adults. Four were accidental and one was with suicidal intent. Two patients developed symptoms probably related to sirolimus overdose: mild elevation of alkaline phosphatase, fever and gastroenteritis in a 2.5-year-old male who ingested 3 mg, and mild changes in total cholesterol in an 18-year-old female

SUBMITTER: Ceschi A 

PROVIDER: S-EPMC4447358 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature