A distinct regulatory region of the Bmp5 locus activates gene expression following adult bone fracture or soft tissue injury.

ABSTRACT: Bone morphogenetic proteins (BMPs) are key signaling molecules required for normal development of bones and other tissues. Previous studies have shown that null mutations in the mouse Bmp5 gene alter the size, shape and number of multiple bone and cartilage structures during development. Bmp5 mutations also delay healing of rib fractures in adult mutants, suggesting that the same signals used to pattern embryonic bone and cartilage are also reused during skeletal regeneration and repair. Despite intense interest in BMPs as agents for stimulating bone formation in clinical applications, little is known about the regulatory elements that control developmental or injury-induced BMP expression. To compare the DNA sequences that activate gene expression during embryonic bone formation and follo

SUBMITTER: Guenther CA 

PROVIDER: S-EPMC4447581 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature