Rapid administration technique of ketamine for pediatric forearm fracture reduction: a dose-finding study.

ABSTRACT:

Study objective

We estimate the minimum dose and total sedation time of rapidly infused ketamine that achieves 3 to 5 minutes of effective sedation in children undergoing forearm fracture reduction in the emergency department.

Methods

We used the up-down method to estimate the median dose of intravenous ketamine infused during less than or equal to 5 seconds that provided effective sedation in 50% (ED50) and 95% (ED95) of healthy children aged 2 to 5, 6 to 11, or 12 to 17 years who were undergoing forearm fracture reduction. Most patients were pretreated with opioids. Three investigators blinded to ketamine dose independently graded sedation effectiveness by viewing a video recording of the first 5 minutes of sedation. Recovery was assessed by modified Aldrete score.

Resu

SUBMITTER: Chinta SS 

PROVIDER: S-EPMC4447585 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature