Altered white matter in cocaine-dependent subjects with traumatic brain injury: A diffusion tensor imaging study.

ABSTRACT:

Background

Diffusion tensor imaging (DTI) is a useful technique for non-invasively investigating the microstructural organization of white matter (WM), and the most consistent DTI finding regarding cocaine-related WM alterations is in the corpus callosum (CC). WM injury has also been observed in subjects with traumatic brain injury (TBI), including in the CC.

Methods

We used DTI to test if the WM microstructure is relatively more impaired in cocaine-dependent subjects who had suffered a mild TBI (mTBI). Fractional anisotropy (FA), which reflects the degree of alignment of cellular structures within fiber tracts and their structural integrity, was compared across cocaine-dependent subjects with mTBI (COCTBI group, n = 9), matched cocaine-dependent subjects without TBI (COC gr

SUBMITTER: Ma L 

PROVIDER: S-EPMC4447586 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature