Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI.

ABSTRACT:

Background

To improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers.

Methods

Two short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at two orientations, one in the anterior commissure-posterior commissure (AC-PC) plane and the second tilted in the AC-PC +15° plane were obtained at 3 Tesla in a group of 10 healthy volunteers. B1 (+) , B1 (-) , and B0 correction procedures and normalization of metabolite signals with quantitative water proton density measurements were performed. A combination of the two spatially normalized 3D-MRSI, using a weighted mean based on the pixel wise stand

SUBMITTER: Lecocq A 

PROVIDER: S-EPMC4447620 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature