A network model of a cooperative genetic landscape in brain tumors.

ABSTRACT:

Context

Gliomas, particularly glioblastomas, are among the deadliest of human tumors. Gliomas emerge through the accumulation of recurrent chromosomal alterations, some of which target yet-to-be-discovered cancer genes. A persistent question concerns the biological basis for the coselection of these alterations during gliomagenesis.

Objectives

To describe a network model of a cooperative genetic landscape in gliomas and to evaluate its clinical relevance.

Design, setting, and patients

Multidimensional genomic profiles and clinical profiles of 501 patients with gliomas (45 tumors in an initial discovery set collected between 2001 and 2004 and 456 tumors in validation sets made public between 2006 and 2008) from multiple academic centers in the United States and The Can

SUBMITTER: Bredel M 

PROVIDER: S-EPMC4447713 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature