Overrepresentation of the COL3A1 AA genotype in Polish skiers with anterior cruciate ligament injury.

ABSTRACT: Although various intrinsic and extrinsic risk factors for anterior cruciate ligament (ACL) rupture have been identified, the exact aetiology of the injury is not yet fully understood. Type III collagen is an important factor in the repair of connective tissue, and certain gene polymorphisms may impair the tensile strength. The aim of this study was to examine the association of the COL3A1 rs1800255 polymorphism with ACL rupture in Polish male recreational skiers. A total of 321 male Polish recreational skiers were recruited for this study; 138 had surgically diagnosed primary ACL ruptures (ACL-injured group) and 183 were apparently healthy male skiers (control group - CON) who had no self-reported history of ligament or tendon injury. Both groups had a comparable level of exposure to ACL i

SUBMITTER: Stepien-Slodkowska M 

PROVIDER: S-EPMC4447760 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature