Associations of Endothelial System Genes With Blood Pressure Changes and Hypertension Incidence: The GenSalt Study.

ABSTRACT:

Background

We used single-marker and novel gene-based methods to examine the associations of endothelial system genes with blood pressure (BP) changes and hypertension in a longitudinal family study.

Methods

The Genetic Epidemiology Network of Salt Sensitivity follow-up study was conducted among 1,768 Chinese participants from 633 families. Nine BP measurements were obtained at baseline and at 2 follow-up visits using a random-zero sphygmomanometer. Mixed-effect models were used to assess the additive associations of 206 single-nucleotide polymorphisms (SNPs) in 15 endothelial system genes with longitudinal BP changes and hypertension incidence. Gene-based analyses were conducted using the truncated product method. The Bonferroni method was used to adjust for multiple testin

SUBMITTER: Liu F 

PROVIDER: S-EPMC4447818 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature