Should Blood Pressure Targets After Lacunar Stroke Vary by Body Size? The SPS3 Trial.

ABSTRACT:

Background

It is unknown whether the physiological impact of a given blood pressure (BP) varies by body size. We explored interactions between higher vs. lower systolic BP (SBP) targets and anthropometric measures (body mass index (BMI), body surface area (BSA), height, weight) and recurrent stroke and death in the Secondary Prevention of Small Subcortical Strokes (SPS3) Trial.

Methods

Patients with recent magnetic resonance imaging-proven lacunar infarcts were randomized to 2 BP targets (130-149 mm Hg vs. <130) in a prospective, open-label, blinded end-point design. Time to outcome was evaluated with Cox proportional hazard models and compared between targets. We examined multiplicative interactions between each anthropometric measure and target and mean difference in achie

SUBMITTER: Field TS 

PROVIDER: S-EPMC4447819 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature