Myc regulates programmed cell death and radial glia dedifferentiation after neural injury in an echinoderm.

ABSTRACT:

Background

Adult echinoderms can completely regenerate major parts of their central nervous system even after severe injuries. Even though this capacity has long been known, the molecular mechanisms that drive fast and complete regeneration in these animals have remained uninvestigated. The major obstacle for understanding these molecular pathways has been the lack of functional genomic studies on regenerating adult echinoderms.

Results

Here, we employ RNA interference-mediated gene knockdown to characterize the role of Myc during the early (first 48 hours) post-injury response in the radial nerve cord of the sea cucumber Holothuria glaberrima. Our previous experiments identified Myc as the only pluripotency-associated factor, whose expression significantly increased in the

SUBMITTER: Mashanov VS 

PROVIDER: S-EPMC4448152 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature