Allelic imbalance at the HER2/TOP2A locus in breast cancer.

ABSTRACT:

Background

Breast cancer is a heterogeneous disease with various histological features and molecular markers. These are utilized for the prediction of clinical outcome and therapeutic decision making. In addition to well established markers such as HER2 overexpression and estrogen and progesterone receptor (ER and PR) status, chromosomal instability is evolving as an important hallmark of cancers. The HER2/TOP2A locus is of great importance in breast cancer. The copy number variability at this locus has been proposed to be a marker for the degree of chromosomal instability. We therefore developed a Single Nucleotide Polymorphism (SNP) assay to evaluate allelic imbalance at the HER2/TOP2A locus in three different entities of primary breast tumors.

Methods

Eleven SNPs were car

SUBMITTER: Huijsmans CJ 

PROVIDER: S-EPMC4448206 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature