Plasticity of fibroblasts demonstrated by tissue-specific and function-related proteome profiling.

ABSTRACT:

Background

Fibroblasts are mesenchymal stromal cells which occur in all tissue types. While their main function is related to ECM production and physical support, they are also important players in wound healing, and have further been recognized to be able to modulate inflammatory processes and support tumor growth. Fibroblasts can display distinct phenotypes, depending on their tissue origin, as well as on their functional state.

Results

In order to contribute to the proteomic characterization of fibroblasts, we have isolated primary human fibroblasts from human skin, lung and bone marrow and generated proteome profiles of these cells by LC-MS/MS. Comparative proteome profiling revealed characteristic differences therein, which seemed to be related to the cell's tissue orig

SUBMITTER: Slany A 

PROVIDER: S-EPMC4448269 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature