Secondary structural entropy in RNA switch (Riboswitch) identification.

ABSTRACT:

Background

RNA regulatory elements play a significant role in gene regulation. Riboswitches, a widespread group of regulatory RNAs, are vital components of many bacterial genomes. These regulatory elements generally function by forming a ligand-induced alternative fold that controls access to ribosome binding sites or other regulatory sites in RNA. Riboswitch-mediated mechanisms are ubiquitous across bacterial genomes. A typical class of riboswitch has its own unique structural and biological complexity, making de novo riboswitch identification a formidable task. Traditionally, riboswitches have been identified through comparative genomics based on sequence and structural homology. The limitations of structural-homology-based approaches, coupled with the assumption that there is a

SUBMITTER: Manzourolajdad A 

PROVIDER: S-EPMC4448311 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature