Spectral analysis of pair-correlation bandwidth: application to cell biology images.

ABSTRACT: Images from cell biology experiments often indicate the presence of cell clustering, which can provide insight into the mechanisms driving the collective cell behaviour. Pair-correlation functions provide quantitative information about the presence, or absence, of clustering in a spatial distribution of cells. This is because the pair-correlation function describes the ratio of the abundance of pairs of cells, separated by a particular distance, relative to a randomly distributed reference population. Pair-correlation functions are often presented as a kernel density estimate where the frequency of pairs of objects are grouped using a particular bandwidth (or bin width), Δ>0. The choice of bandwidth has a dramatic impact: choosing Δ too large produces a pair-correlation function that conta

SUBMITTER: Binder BJ 

PROVIDER: S-EPMC4448803 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature