Adipose stromal cells repair pressure ulcers in both young and elderly mice: potential role of adipogenesis in skin repair.

ABSTRACT:

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More than 2.5 million patients in the U.S. require treatment for pressure ulcers annually, and the elderly are at particularly high risk for pressure ulcer development. Current therapy for pressure ulcers consists of conservative medical management for shallow lesions and aggressive debridement and surgery for deeper lesions. The current study uses a murine model to address the hypothesis that adipose-derived stromal/stem cell (ASC) treatment would accelerate and enhance pressure ulcer repair. The dorsal skin of both young (2 months old [mo]) and old (20 mo) C57BL/6J female mice was sandwiched between external magnets for 12 hours over 2 consecutive days to initiate a pressure ulcer. One day following the induction, mice were injected with ASCs isolated from congenic mic

SUBMITTER: Strong AL 

PROVIDER: S-EPMC4449094 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature