Application of a drug-induced apoptosis assay to identify treatment strategies in recurrent or metastatic breast cancer.

ABSTRACT:

Background

A drug-induced apoptosis assay has been developed to determine which chemotherapy drugs or regimens can produce higher cell killing in vitro. This study was done to determine if this assay could be performed in patients with recurrent or metastatic breast cancer patients, to characterize the patterns of drug-induced apoptosis, and to evaluate the clinical utility of the assay. A secondary goal was to correlate assay use with clinical outcomes.

Methods

In a prospective, non-blinded, multi institutional controlled trial, 30 evaluable patients with recurrent or metastatic breast cancer who were treated with chemotherapy had tumor samples submitted for the MiCK drug-induced apoptosis assay. After receiving results within 72 hours after biopsy, physicians could use the

SUBMITTER: Bosserman L 

PROVIDER: S-EPMC4449169 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature