Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.

ABSTRACT:

Objectives

To identify genetic associations with hip osteoarthritis (HOA), we performed a meta-analysis of genome-wide association studies (GWAS) of HOA.

Methods

The GWAS meta-analysis included approximately 2.5 million imputed HapMap single nucleotide polymorphisms (SNPs). HOA cases and controls defined radiographically and by total hip replacement were selected from the Osteoporotic Fractures in Men (MrOS) Study and the Study of Osteoporotic Fractures (SOF) (654 cases and 4697 controls, combined). Replication of genome-wide significant SNP associations (p ≤5×10(-8)) was examined in five studies (3243 cases and 6891 controls, combined). Functional studies were performed using in vitro models of chondrogenesis and osteogenesis.

Results

The A allele of rs788748, locate

SUBMITTER: Evans DS 

PROVIDER: S-EPMC4449305 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature