Incorporating linked healthcare claims to improve confounding control in a study of in-hospital medication use.

ABSTRACT:

Introduction

The Premier Perspective hospital billing database provides a promising data source for studies of inpatient medication use. However, in-hospital recording of confounders is limited, and incorporating linked healthcare claims data available for a subset of the cohort may improve confounding control. We investigated methods capable of adjusting for confounders measured in a subset, including complete case analysis, multiple imputation of missing data, and propensity score (PS) calibration.

Methods

Methods were implemented in an example study of adults in Premier undergoing percutaneous coronary intervention (PCI) in 2004-2008 and exposed to either bivalirudin or heparin. In a subset of patients enrolled in UnitedHealth for at least 90 days before hospitalization,

SUBMITTER: Franklin JM 

PROVIDER: S-EPMC4449313 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature