Application of M13 phage display for identifying immunogenic proteins from tick (Ixodes scapularis) saliva.

ABSTRACT:

Background

Ticks act as vectors for a large number of different pathogens, perhaps most notably Borrelia burgdorferi, the causative agent of Lyme disease. The most prominent tick vector in the United States is the blacklegged tick, Ixodes scapularis. Tick bites are of special public health concern since there are no vaccines available against most tick-transmitted pathogens. Based on the observation that certain non-natural host animals such as guinea pigs or humans can develop adaptive immune responses to tick bites, anti-tick vaccination is a potential approach to tackle health risks associated with tick bites.

Results

The aim of this study was to use an oligopeptide phage display strategy to identify immunogenic salivary gland proteins from I. scapularis that are recogniz

SUBMITTER: Becker M 

PROVIDER: S-EPMC4449557 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature