Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder.

ABSTRACT: Frontotemporal neural systems are highly implicated in the emotional dysregulation characteristic of bipolar disorder (BD). Convergent genetic, postmortem, behavioral and neuroimaging evidence suggests abnormalities in the development of frontotemporal white matter (WM) in the pathophysiology of BD. This review discusses evidence for the involvement of abnormal WM development in BD during adolescence, with a focus on frontotemporal WM. Findings from diffusion tensor imaging (DTI) studies in adults and adolescents are reviewed to explore possible progressive WM abnormalities in the disorder. Intra- and interhemispheric frontotemporal abnormalities were reported in adults with BD. Although evidence in children and adolescents with BD to date has been limited, similar intrahemispheric and int

SUBMITTER: de Zwarte SM 

PROVIDER: S-EPMC4449671 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature