Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner.

ABSTRACT: YY1 can activate or repress transcription of various genes. In cardiac myocytes in culture YY1 has been shown to regulate expression of several genes involved in myocyte pathology. YY1 can also acutely protect the heart against detrimental changes in gene expression. In this study we show that cardiac over-expression of YY1 induces pathologic cardiac hypertrophy in male mice, measured by changes in gene expression and lower ejection fraction/fractional shortening. In contrast, female animals are protected against pathologic gene expression changes and cardiac dysfunction. Furthermore, we show that YY1 regulates, in a sex-specific manner, the expression of mammalian enable (Mena), a factor that regulates cytoskeletal actin dynamics and whose expression is increased in several models of card

SUBMITTER: Stauffer BL 

PROVIDER: S-EPMC4449792 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature