Human adenoviruses role in ophthalmic pterygium formation.

ABSTRACT: BACKGROUND:Ophthalmic pterygium is a common benign lesion of unknown origin and the pathogenesis might be vision-threatening. This problem is often associated with exposure to solar light. Recent evidence suggests that potentially oncogenic viruses such as human papillomavirus and Epstein-Barr virus may be involved in the pathogenesis of pterygia. Expression of specific adenovirus genes such as E1A and E1B, which potentially have many functions, may contribute to their oncogenic activity as well as relevance to cellular immortalization. OBJECTIVES:For the first time, we aimed to investigate involvement of adenoviruses in pterygium formation. PATIENTS AND METHODS:Fifty tissue specimens of pterygium from patients undergoing pterygium surgery (as cases), 50 conjunctival swab samples from the

SUBMITTER: Kelishadi M 

PROVIDER: S-EPMC4449841 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature