Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex.

ABSTRACT: The innate immune response plays a key role in fighting infection by activating inflammation and stimulating the adaptive immune response. However, chronic activation of innate immunity can contribute to the pathogenesis of many diseases with an inflammatory component. Thus, various negatively acting factors turn off innate immunity subsequent to its activation to ensure that inflammation is self-limiting and to prevent inflammatory disease. These negatively acting pathways include the production of inhibitory acting alternate proteins encoded by alternative mRNA splice forms of genes in Toll-like receptor (TLR) signaling pathways. We previously found that the SF3a mRNA splicing complex was required for a robust innate immune response; SF3a acts to promote inflammation in part by inhibitin

SUBMITTER: O'Connor BP 

PROVIDER: S-EPMC4450051 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature