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Endplate deflection is a defining feature of vertebral fracture and is associated with properties of the underlying trabecular bone.


ABSTRACT: Endplate deflection frequently occurs with vertebral failure, but the relationship between the two remains poorly defined. This study examined associations between endplate deflection under compressive loading and characteristics of the neighboring subchondral bone and intervertebral disc (IVD). Ten L1 vertebrae with adjacent IVDs were dissected, compressed axially in a stepwise manner to failure, and imaged with micro-computed tomography before each loading step. From the images, deflection was measured across the surface of each endplate at each step. Trabecular microstructure and endplate volume fraction were evaluated in 5?mm regions just under the superior endplate. IVDs were assessed using computed tomography and histology. A marked increase in superior endplate deflection coincided with a drop in the load-displacement curve. Endplate deflection was higher in regions with less robust bone microstructure (p?

SUBMITTER: Jackman TM 

PROVIDER: S-EPMC4450106 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Endplate deflection is a defining feature of vertebral fracture and is associated with properties of the underlying trabecular bone.

Jackman Timothy M TM   Hussein Amira I AI   Adams Alexander M AM   Makhnejia Kamil K KK   Morgan Elise F EF  

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20140402 7


Endplate deflection frequently occurs with vertebral failure, but the relationship between the two remains poorly defined. This study examined associations between endplate deflection under compressive loading and characteristics of the neighboring subchondral bone and intervertebral disc (IVD). Ten L1 vertebrae with adjacent IVDs were dissected, compressed axially in a stepwise manner to failure, and imaged with micro-computed tomography before each loading step. From the images, deflection was  ...[more]

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