Helicobacter pylori neutrophil-activating protein: a potential Treg modulator suppressing allergic asthma?

ABSTRACT: The ultimate aim of the immune system is to eliminate pathogens without being harmful to the host. But what if eliminating the pathogen in itself is discomforting for the host? One such emerging case is of Helicobacter pylori. Modern medicine, infantile vaccination, and ultra-hygienic conditions have led to progressive disappearance of H. pylori in different parts of the world. However, the adversities caused by H. pylori's absence are much larger than those caused by its presence. Asthma is rising as an epidemic in last few decades and several reports suggest an inverse-relationship between H. pylori's persistence and early-life onset asthma. Regulatory T cells play an important role in both the cases. This is further supported by experiments on mouse-models. Hence, need of the hour is to

SUBMITTER: Sehrawat A 

PROVIDER: S-EPMC4450655 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature