A study on immunomodulatory mechanism of Polysaccharopeptide mediated by TLR4 signaling pathway.

ABSTRACT:

Background

Polysaccharopeptide (PSP), isolated from Coriolus versicolor COV-1 strain, is a protein-bound polysaccharide widely used as immunoadjuvant for cancer immunotherapy. Although the immunomodulatory activity of PSP has been well established, the precise molecule mechanisms of its biological activity have yet to be fully elucidated.

Methods

In the present study, we first investigated the immunomodulatory activity of PSP in peritoneal macrophages from C57BL/10J (TLR4(+/+)) and C57BL/10ScCr (TLR4(-/-)) mice carrying a defective toll-like receptor-4 (TLR4) gene and then evaluated PSP for its effect on tumor inhibition rates and the immune organ index in above two different strains of mice. In addition, PSP were also evaluated for its activation of TLR4, TLR4-downstream mo

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4450994 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature