Imiquimod cream efficacy in the treatment of periocular nodular basal cell carcinoma: a non-randomized trial.

ABSTRACT:

Background

The recurrence rate of periocular nodular basal cell carcinoma (PNBCC) following treatment with imiquimod (IMQ) has not yet been established. Previous studies did not include histological follow-up. The aim of this analysis was to evaluate the efficacy of topical immunotherapy with 5% IMQ cream for the treatment of PNBCC.

Methods

Study design

A prospective, non-randomized, and uncontrolled longitudinal case series study. No participants were blinded. Punch biopsy confirmed PNBCC patients were included at the Ophthalmology Clinic of São Paulo University Medicine School Hospital (from 2008 to 2012). Patients were treated with 5% IMQ cream once a day, 5 days per week, for 8-16 weeks. Standard lesion photographic documentation was done during the study. Three

SUBMITTER: de Macedo EM 

PROVIDER: S-EPMC4450997 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature