MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells.

ABSTRACT: RNA interference-related silencing mechanisms concern very diverse and distinct biological processes, from gene regulation (via the microRNA pathway) to defense against molecular parasites (through the small interfering RNA and the Piwi-interacting RNA pathways). Small non-coding RNAs serve as specificity factors that guide effector proteins to ribonucleic acid targets via base-pairing interactions, to achieve transcriptional or post-transcriptional regulation. Because of the small sequence complementarity required for microRNA-dependent post-transcriptional regulation, thousands of microRNA (miRNA) putative targets have been annotated in Drosophila. In Drosophila somatic ovarian cells, genomic parasites, such as transposable elements (TEs), are transcriptionally repressed by chromatin cha

SUBMITTER: Mugat B 

PROVIDER: S-EPMC4451950 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature