Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis.

ABSTRACT: Metastasis associated in colon cancer 1 (MACC1), a newly identified oncogene, has been associated with poor survival of cancer patients by multiple studies. However, the prognostic value of MACC1 in digestive system neoplasms needs systematic evidence to verify. Therefore, we aimed to provide further evidence on this topic by systematic review and meta-analysis. Literature search was conducted in multiple databases and eligible studies analyzing survival data and MACC1 expression were included for meta-analysis. Hazard ratio (HR) for clinical outcome was chosen as an effect measure of interest. According to our inclusion criteria, 18 studies with a total of 2,948 patients were identified. Pooled HRs indicated that high MACC1 expression significantly correlates with poorer OS in patients wi

SUBMITTER: Wu Z 

PROVIDER: S-EPMC4452247 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature