Racial variation in breast tumor promoter methylation in the Carolina Breast Cancer Study.

ABSTRACT:

Background

African American (AA) women are diagnosed with more advanced breast cancers and have worse survival than white women, but a comprehensive understanding of the basis for this disparity remains unclear. Analysis of DNA methylation, an epigenetic mechanism that can regulate gene expression, could help to explain racial differences in breast tumor clinical biology and outcomes.

Methods

DNA methylation was evaluated at 1,287 CpGs in the promoters of cancer-related genes in 517 breast tumors of AA (n = 216) or non-AA (n = 301) cases in the Carolina Breast Cancer Study (CBCS).

Results

Multivariable linear regression analysis of all tumors, controlling for age, menopausal status, stage, intrinsic subtype, and multiple comparisons [false discovery rate (FDR)], ident

SUBMITTER: Conway K 

PROVIDER: S-EPMC4452445 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature