Adult body size and physical activity in relation to risk of breast cancer according to tumor androgen receptor status.

ABSTRACT:

Background

Obesity and physical activity have been hypothesized to affect breast cancer risk partly via the androgen signaling pathway. We conducted the first study to evaluate these associations by tumor androgen receptor (AR) status.

Methods

Height, weight, and physical activity were assessed using questionnaires in the Nurses' Health Study. AR, estrogen receptor (ER), and progesterone receptor (PR) status were determined using immunohistochemistry on tumor tissue and medical/pathology reports.

Results

A total of 1,701 AR(+) and 497 AR(-) cases were documented during 26 years of follow-up of 103,577 women. After adjusting for ER/PR status and other risk factors, the relative risks (RR) and 95% confidence intervals (95% CI) for every 5 kg/m(2) increase in body mass i

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4452447 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature