Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal adenocarcinoma.

ABSTRACT:

Objective

Recently, single nucleotide polymorphisms (SNPs) associated with esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) were identified; rs10419226 (CRTC1), rs11789015 (BARX1), rs2687201 (FOXP1), rs2178146 (FOXF1), rs3111601 (FOXF1), and rs9936833 (FOXF1). These findings indicate that genetic susceptibility could play a role in the initiation of EAC in BE patients. The aim of this study was to validate the association between these previously identified SNPs and the risk of EAC in an independent and large case-control study.

Design

Six SNPs found to be associated with EAC and BE were genotyped by a multiplex SNaPshot analysis in 1071 EAC patients diagnosed and treated in the Netherlands. Allele frequencies were compared to a control group derived from the Rot

SUBMITTER: van Nistelrooij AM 

PROVIDER: S-EPMC4453126 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature