PReVENT--protective ventilation in patients without ARDS at start of ventilation: study protocol for a randomized controlled trial.

ABSTRACT:

Background

It is uncertain whether lung-protective mechanical ventilation using low tidal volumes should be used in all critically ill patients, irrespective of the presence of the acute respiratory distress syndrome (ARDS). A low tidal volume strategy includes use of higher respiratory rates, which could be associated with increased sedation needs, a higher incidence of delirium, and an increased risk of patient-ventilator asynchrony and ICU-acquired weakness. Another alleged side-effect of low tidal volume ventilation is the risk of atelectasis. All of these could offset the beneficial effects of low tidal volume ventilation as found in patients with ARDS.

Methods/design

PReVENT is a national multicenter randomized controlled trial in invasively ventilated ICU patients wit

SUBMITTER: Simonis FD 

PROVIDER: S-EPMC4453265 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature