Diabetes mellitus and platelet reactivity in patients under prasugrel or ticagrelor treatment: an observational study.

ABSTRACT:

Background

The influence of diabetes mellitus (DM) on platelet reactivity (PR) in prasugrel or ticagrelor treated patients is not well studied.

Methods

In an observational study involving 777 patients with acute coronary syndrome undergoing percutaneous coronary intervention treated by either prasugrel 10 mg od (n = 315) or ticagrelor 90 mg bid (n = 462), platelet function was assessed using the VerifyNow P2Y12 function assay (in PRU) at one month post intrvention.

Results

In the overall population, ticagrelor and insulin-treated DM affected PR, with a decrease in log by 0.88 (corresponding to a 58 % decrease in PR) compared to prasugrel-treated patients (p < 0.001), and an increase in log by 0.26 (corresponding to a 30 % increase in PR) compared to non-diabetic patie

SUBMITTER: Alexopoulos D 

PROVIDER: S-EPMC4453292 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature